Synthesis of Glycopeptides with Partial Structure of Human Glycophorin Using the Fluorenylmethoxycarbonyl/ Allyl Ester Protecting Group Combination

Abstract

Glycopeptide partial structures of glycophorin A are synthesized with Tn antigen type monosaccharide and T antigen type disaccharide side chains O-glycosidically linked to serine or threonine. The N-terminal 9-fluorenylmethoxycarbonyl (Fmoc) group and the C-terminal allyl ester were used as orthogonally stable, selectively removable protecting groups.