Benzofuran systems. Synthesis and biological examination of 1‐(3‐benzofuranyl)‐2‐phenylethanones

Abstract

Abstract Novel 1‐(3‐benzofuranyl)‐2‐phcnylethanones 4a‐d have been prepared by acetylation of 2‐alkylbenzo‐furans 2a‐c with phenylacetyl chlorides 3a‐b . The methoxy derivatives 4b‐d have been demethylated to the corresponding phenols 5b‐d with pyridinium hydrochloride. An attempt to obtain the derivatives of 4d and 5a iodinated in the phenyl ring has been undertaken. The novel compounds have been characterized by ir and nmr spectra and their biological activity examined.