Concepedia

YM-202204, a New Antifungal Antibiotic Produced by Marine Fungus Phoma sp.

Koji Nagai, KAZUMA KAMIGIRI, Hisao Matsumoto, Yasuhiro Kawano, Masakazu Yamaoka, Hitoshi Shimoi, Masato Watanabe, Kenichi Suzuki

The Journal of Antibiotics · 2002 · 52 citations · 11 references

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Abstract

A new antifungal antibiotic, YM-202204 (1), was found in the culture broth of marine fungus Phoma sp. Q60596. The structure of 1 was determined by several spectroscopic experiments as a new lactone compound. This antibiotic exhibited potent antifungal activities against Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus, and also inhibited glycosyl-phosphatidyl-inositol (GPI)-anchoring in yeast cells.

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