Synthesis and Pharmacological Investigation of 3‐Subsituted‐amino‐2‐methylsulfanyl‐5,6,7,8‐tetrahydro‐3<i>H</i>‐benzo[4,5]thieno[2,3‐<i>d</i>]pyrimidin‐4‐ones as Analgesic and Anti‐Inflammatory Agents

Abstract

In the present work, design, synthesis, and pharmacological evaluation of the analgesic, anti-inflammatory, and ulcerogenic-index activities of new 3-subsituted-amino-2-methylsulfanyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-ones, structurally planed by exploiting a clear concept of bio-isosterism, are reported. All compounds exhibited significant analgesic and anti-inflammatory activity. Compounds A1, A3 showed higher analgesic activity and more potent anti-inflammatory activity than that of the reference compound diclofenac sodium. Interestingly, the test compounds showed only mild ulcerogenic potential when compared to that of acetylsalicylic acid.