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Cyanoacetylation of Indoles, Pyrroles and Aromatic Amines with the Combination Cyanoacetic Acid and Acetic Anhydride
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2004
Year
Cyanoacetic AcidDerivative (Chemistry)EngineeringAcetic AnhydrideAromatic AminesOrganic ChemistryAniline DerivativesStereoselective SynthesisChemistryHeterocycle ChemistryPharmacologyChemical DerivativeSynthetic ChemistryEnantioselective SynthesisBiomolecular EngineeringCombination Cyanoacetic AcidNatural Product Synthesis
Cyanoacetic acid was activated with acetic anhydride and when heated this reagent reacted with a variety of both activated and deactivated pyrroles, indoles and aniline derivatives.