Stereoselective Synthesis of Monocyclic β-Lactam Related to a Carmonam Precursor via Ketene-Imine Reaction

Abstract

Reaction of chiral imine derived from (L)-malic acid with acid chlorides from glycine derivatives in the presence of triethylamine afforded optically active cis-substituted β-lactam, which in turn was transformed into a carmonam precursor with excellent stereoselectivity.