Publication | Closed Access
Direct Addition of TMS-acetylene to Aldimines Catalyzed by a Simple, Commercially Available Ir(I) Complex
256
Citations
27
References
2001
Year
EngineeringOrganic ChemistryDirect AdditionChemistryHeterocycle ChemistryConvenient ProcedureChemical EngineeringOrganometallic CatalysisAddition ReactionInorganic ChemistryCross-coupling ReactionCatalysisAsymmetric CatalysisEnantioselective SynthesisBiomolecular EngineeringCommercially Available IrTrimethylsilyl AcetyleneAlkene MetathesisSynthetic Chemistry
A new, convenient procedure for the addition reaction of trimethylsilylacetylene to imines is described. Simply treating a solution of aldimine and trimethylsilyl acetylene with catalytic [IrCl(COD)](2) furnishes the adduct in preparatively useful yields. Interestingly, the reaction may be conducted in the absence of solvent. [reaction: see text]
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