Palladium-Catalyzed Chelation-Assisted C–H Bond Halogenation: Selective Chlorination of 2-Arylpyridines with Acid Chlorides - Concepedia

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Palladium-Catalyzed Chelation-Assisted C–H Bond Halogenation: Selective Chlorination of 2-Arylpyridines with Acid Chlorides

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2014

Year

Farnaz Jafarpour, Hamideh Hazrati, Samaneh Zarei, Sara Izadidana

Chemical EngineeringAryl ChloridesEngineeringAcid ChloridesNatural SciencesDiversity-oriented SynthesisPrivileged MotifsOrganic ChemistryOrganometallic CatalysisCatalysisChemistrySelective ChlorinationHalogenation

Abstract

Palladium-catalyzed chelation-assisted C–H bond halogenation of arenes using acid chlorides as chlorinating agents is reported. This method provides a monoselective, straightforward, and clean route for the construction of aryl chlorides as privileged motifs in organic transformations.