Synthesis of Functionalized 5-Oxo-2,5-dihydro-1<i>H</i>-pyrroles from Primary Alkylamines, Oxalyl Chloride, and Dimethyl Acetylenedicarboxylate - Concepedia

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Synthesis of Functionalized 5-Oxo-2,5-dihydro-1<i>H</i>-pyrroles from Primary Alkylamines, Oxalyl Chloride, and Dimethyl Acetylenedicarboxylate

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2008

Year

Issa Yavari, Sanaz Souri

Chemical EngineeringEngineeringDimethyl AcetylenedicarboxylatePrimary AlkylaminesOxalyl ChlorideOrganic ChemistryCatalysisStereoselective SynthesisChemistryHeterocycle ChemistrySynthesis MethodSynthetic ChemistryBiomolecular Engineering

Abstract

An efficient synthesis of dimethyl 1-alkyl-2,4-dihydroxy-5-oxo-2,5-dihydro-1H-pyrrole-2,3-dicarboxylates is described via a three-component reaction between primary alkylamines, oxalyl chloride, and dimethyl acetylenedicarboxylate.