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Synthesis of Novel Chiral Thiophene-, Benzothiophene- and Benzofuran-Oxazoline Ligands and their Use in the Enantioselective Pd-Catalyzed Allylation
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2002
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Enantioselective Pd-catalyzed AllylationNew LigandsEngineeringHeterocyclicNatural SciencesDiversity-oriented SynthesisOrganic ChemistryBenzofuran-oxazoline LigandsCatalysisNovel ThiopheneChemistryHeterocycle ChemistryStereoselective SynthesisNovel Chiral Thiophene-Asymmetric CatalysisEnantioselective SynthesisBiomolecular Engineering
Novel thiophene, benzothiophene and benzofuran-oxazoline ligands 6-11 containing a diphenylphosphino group at different positions of the heterocyclic skeleton have been prepared and used in the enantioselective allylation. The advantage of these new ligands is their easy accessibility and their high reactivity. The best results were obtained with ligand 9 to give the product 13 in 97.0% ee with 92% yield in 2 hours at 0 °C.