Nitroimidazolones. Synthesis of Deaza Analogues of 3-Nitro-1,2,4-triazol-5-one

Abstract

Analogues of 3-niuo-12,4-mazol-5-one (NTO) have been synthesized.The strategy revolves around a new method for the synthesis of imidazolones.namely the addition-elimination reaction of the sodium salt of mmethylsilylethanol with a mmethylsilylethoxymethyl @EM)-protected dinimimidazole followed by the acid-catalyzed conversion to the desired nitroimidazole (5).The N-methyl derivatives of 5 were prepared in a similar manner starting from the Nmethyldinimimidazoles.