Publication | Closed Access
Regioselective Preparation of Pyridin-2-yl Ureas from 2-Chloropyridines Catalyzed by Pd(0)
34
Citations
0
References
2005
Year
Chemical EngineeringCross-coupling ReactionEngineeringAliphatic UreasOrganic ChemistryOrganometallic CatalysisCatalysisPalladium-catalyzed Ureidation ReactionChemistryRegioselective PreparationMolecular CatalysisAsymmetric CatalysisGood YieldSynthetic ChemistryCatalytic Synthesis
The palladium-catalyzed ureidation reaction of 2-chloropyridines can be regioselectively performed in good yield, with both aryl and aliphatic ureas, using xantphos as the ligand, Pd(OAc)2 as the source of palladium, NaOt-Bu/H2O or NaOH/H2O as the base, and dioxane as the solvent