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Asymmetric Addition to Chiral Aromatic and Unsaturated Oxazolines Using a Novel Chiral Auxiliary
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1993
Year
Novel Chiral AuxiliaryAsymmetric AdditionCorresponding OxazolinesNaphthalenes 22Chiral AromaticOrganic ChemistryStereoselective SynthesisChemistryMethoxyamino AlcoholPharmacologyAsymmetric CatalysisDerivative (Chemistry)Synthetic ChemistryEnantioselective SynthesisNatural Product Synthesis
By utilizing S-serine, both enantiomers of the reduced methoxyamino alcohol (12) were efficiently prepared. The corresponding oxazolines, prepared from these auxiliaries, showed favorable properties toward additions to naphthalenes 22 and cyclohexene, 27.