Highly Enantioselective Friedel−Crafts Reaction of Indoles with 2-EnoylPyridine 1-Oxides Catalyzed by Chiral Pyridine 2,6-Bis(5′,5′-diphenyloxazoline)−Cu(II) Complexes

Abstract

The catalytic enantioselective Friedel-Crafts reaction of indoles with 2-enoylpyridine 1-oxides has been studied in the presence of chiral pyridine 2,6-bis(5',5'-diphenyloxazoline)-Cu(II) complexes. The reaction furnished alkylated indoles in excellent yields (up to 97%) and enantioselectivities (up to 99% ee).