Concise Substrate-Controlled Asymmetric Total Synthesis of (+)-3-(Z)-Dihydrorhodophytin

Abstract

The first asymmetric total synthesis of (+)-3-(Z)-dihydrorhodophytin(1) has been accomplished in 15 steps in 17% overall yield from readily available starting material 6 in a substrate-controlled manner.Key steps in our synthesis are a highly stereoselective dianion alkylation for the synthesis of the ,'-anti-RCM substrate and a strategy for the introduction of the chlorine