Synthesis of (+)-(<i>R</i>)-1-Amino-2,2-difluorocyclopropane-1-carboxylic Acid through Lipase-Catalyzed Asymmetric Acetylation - Concepedia

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Synthesis of (+)-(<i>R</i>)-1-Amino-2,2-difluorocyclopropane-1-carboxylic Acid through Lipase-Catalyzed Asymmetric Acetylation

22

Citations

11

References

1999

Year

Masayuki Kirihara, Tomofumi Takuwa, Masashi Kawasaki, Hiroko Kakuda, Shun‐ichi Hirokami, Hiroki Takahata

Chemistry Letters

Key StepEngineeringBiochemistryLipase-catalyzed Asymmetric AcetylationOrganic ChemistryPro-chiral DiolStereoselective SynthesisAsymmetric CatalysisSynthetic ChemistryEnantioselective SynthesisBiomolecular Engineering

Abstract

Abstract (+)-(R)-1-Amino-2,2-difluorocyclopropane-1-carboxylic acid was synthesized via the lipase-catalyzed asymmetric acetylation of a pro-chiral diol as the key step.

References

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