Synthesis of Hydroxamic Esters via Alkoxyaminocarbonylation of β-Dicarbonyl Compounds

Abstract

N - t -Butoxycarbonyl- O -sulfonyl-substituted hydroxylamines react with soft enolates to yield O - t- butoxycarbonylamino derivatives rather than the expected Boc-protected amino acids. The reaction is limited to enolates of β-dicarbonyl compounds. Decarboxylation of the resultant tricarbonyl compound affords malonyl α-alkyl O - t- butoxycarbonylamino derivatives.