Synthesis of Octacarboxytetra(2,3-pyrazino)porphyrazine: Novel Water Soluble Photosensitizers for Photodynamic Therapy

Abstract

(opens in new window) Buy Article (opens in new window) Permissions and Reprints (opens in new window) All articles of this category (opens in new window) The condensation of 2,3-dicyano-5,6-diethoxycarbonylpyrazine with a metal salt affords tetra-2,3-(5,6-diethoxycarbonylpyrazino)porphyrazine, which upon mild hydrolysis yields novel water-soluble metal complexes of tetra-2,3-(5,6-dicarboxypyrazino)porphyrazine. These octaaza analogs of phthalocyanine have potential applications in the field of photodynamic therapy of cancer.