The first synthesis of optically active 1-substituted taurines

Abstract

Optically active 1-substituted taurines, a type of important sulfur analogues of naturally occurring amino acids, and their N-benzyloxycarbonyl-protected derivatives were synthesized from the corresponding optically active β-amino secondary alcohols in three steps via N-protection with benzyl chloroformate, substitution with thiolacetic acid under Mitsunobu conditions, and oxidation with performic acid. © 2005 Wiley Periodicals, Inc. Heteroatom Chem 16:466–471, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20133