Asymmetric Vinylogous Michael Reaction of α,β-Unsaturated Aldehyde with Buteno-4-lactone

Abstract

Abstract The asymmetric vinylogous Michael reactions of α,β-unsaturated aldehydes with γ-butenolide(buteno-4-lactone) were efficiently catalyzed by the Jørgensen–Hayashi catalyst and LiOAc. The desired products were obtained in satisfactory yields with excellent enantioselectivities and moderate diastereoselectivities.