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A Mixed Naphthyl-Phenyl Phosphine Ligand Motif for Suzuki, Heck, and Hydrodehalogenation Reactions
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2006
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Cross-coupling ReactionHeck ReactionsEngineeringHeterocyclicBiochemistryNatural SciencesShort SynthesisOrganic ChemistryOrganometallic CatalysisCatalysisHydrodehalogenation ReactionsChemistryChemical DerivativeSynthetic ChemistryBiomolecular Engineering
Nap-Phos, representing a new naphthyl-phenyl biaryl-type phosphine ligand class and available by a short synthesis (4 steps, 71% overall yield), effectively catalyzes the Suzuki-Miyaura (including highly hindered cases), hydrodehalogenation, and Heck reactions.