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Synthesis of 2-Nitroalcohols by Regioselective Ring Opening of Epoxides with MgSO4/MeOH/NaNO2 System: A Short Synthesis of Immunosuppressive Agent FTY-720
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2001
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Mgso4/meoh/nano2 SystemRegioselective Ring OpeningBioorganic ChemistryNatural SciencesExcellent YieldsDiversity-oriented SynthesisMedicineShort SynthesisNano-drug DeliveryChemistrySynthesis MethodPharmacologyImmunosuppressive Agent Fty-720Pharmaceutical ChemistrySynthetic ChemistryBiomolecular EngineeringDrug Discovery
It has been demonstrated that a variety of epoxides can easily be opened with a system consisting of MgSO4/MeOH/NaNO2 giving the corresponding 2-nitroalcohols in excellent yields. This strategy has been applied to achieve a short synthesis of Immunosuppressive Agent FTY-720.