Publication | Closed Access
A Facile one pot Synthesis of Highly Substituted 1,6 Naphteyridines
13
Citations
8
References
1999
Year
EngineeringHeterocyclicThorpe-ziegler CyclizationOrganic ChemistryMichael AdditionStereoselective SynthesisChemistryHeterocycle ChemistrySynthetic ChemistryBiomolecular EngineeringHighly Substituted 1,6
Abstract The synthesis of 1,6-naphthyridiner 2a-f by the reaction of chalcones la-f with malononitrile in the presence of pyrrolidine, involving the Michael addition followed by Thorpe-Ziegler cyclization is described.
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