Asymmetric Baylis-Hillman Reaction: An Enchanting Expedition

Abstract

The development of new strategies for realizing the asymmetric Baylis-Hillman reaction remains at the forefront of research into this important organic reaction. This review gives a comprehensive account of the work that has emanated from our group on the asymmetric Baylis-Hillman reaction. Herein, the use of homochiral electrophiles, Michael acceptors, and bases and double asymmetric induction protocols as tools for the asymmetric Baylis-Hillman reaction is discussed. The account also covers the application of such protocols in natural product synthesis.