The synthesis and transformation of ethyl 2‐(2‐acetyl‐2‐benzoyl‐1‐ethenyl)amino‐3‐dimethylaminopropenoate. A new synthesis of 2,3,4‐trisubstituted pyrroles

Abstract

Abstract The synthesis of ethyl 2‐(2‐acetyl‐2‐benzoyl‐1‐ethenyl)amino‐3‐dimethylarninopropenoate ( 4 ) from benzoylacetone ( 1 ) via 3‐dimethylarninomethylenebenzoylacetone ( 2 ) and ethyl N ‐(2‐acetyl‐2‐benzoyl‐1‐ethenyl)glycinate ( 3 ) and its transformation into 4‐benzoyl‐2‐ethoxycarbonyl‐3‐methylpyrrole ( 9 ) is described. Cyclization of 4 into 9 represents a new synthesis of polysubstituted pyrroles.