La(NO<sub>3</sub>)<sub>3</sub>.6H<sub>2</sub>O Catalyzed One-pot Highly Diastereoselective Synthesis of Functionalized Piperidines

Abstract

La(NO3)3.6H2O was used as an efficient catalyst for highly diastereoselective synthesis of functionalized piperidines by one-pot five-component reactions of anilines and aromatic aldehydes with acetoacetic esters. This strategy proceeds by way of the Knoevenagel reaction followed by inter-molecular aza-Diels-Alder reaction. The main features of the current method comprise mild reaction conditions, easy work-up, eco-friendliness, high atom economy, short times and the products were isolated with high yields. Keywords: Lanthanum nitrate hexahydrate, piperidine, one-pot, multicomponent