A Silver Salt -- Iodine Reagent System for the Deprotection of Monothioacetals and Dithioacetals

Abstract

A new reagent (silver saltiodine) system was developed for the deprotection of monothioacetals and dithioacetals.The reactions using this reagent system afforded the parent carbonyl wmpounds in rnoderale to quantitative yields under mild conditions.These deprotections were also effective in the catalytic amount of this reagent.As an application of this deprotective reagent system, synthesizing optically active a-hydroxyaldehyde using chiiall3-oxathiane was demonstlaled.