Synthesis of new uracil non‐nucleoside derivatives as potential inhibitors of HIV‐1

Abstract

Abstract 6‐(2‐Phenylethyl) and 6‐cyclohexyl 5‐cyanouracils ( 1a,b ) were synthesized and reacted with chloromethyl ethyl ether, benzyl chloromethyl ether, chloromethyl methyl sulfide and (2‐acetoxyethoxy)methyl bromide. New uracil analogues of ( S )‐DHPA were synthesized by reaction of compounds ( 1a,b ) with (( S )‐2,2‐dimethyl‐1,3‐dioxolane‐4‐yl) alkyl p ‐toluenesulfonate.