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(<i>S</i>)-Proline as a Neutral and Efficient Catalyst for the One-Pot Synthesis of Tetrahydrobenzo[<i>b</i>]pyran Derivatives in Aqueous Media
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2006
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Simple WorkupAsymmetric CatalysisChemical EngineeringDerivativesEngineeringOne-pot SynthesisActive Methylene CompoundsOrganic ChemistryCatalysisStereoselective SynthesisChemistryAqueous MediaEfficient CatalystNeutral CatalystHeterocycle ChemistrySynthetic ChemistryCatalytic Synthesis
(S)-Proline has been used as a mild, efficient and neutral catalyst for synthesis of various 4H-benzo[b]pyran derivatives via a one-pot three-component condensation of aromatic aldehydes, active methylene compounds, and dimedone in aqueous media. This method offers the advantages of proceeding and neutral and mild conditions, giving high to excellent yields of the products and simple workup.