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Practical Synthesis of KRN7000 from Phytosphingosine
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2004
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Important α-GalactosylceramidesPractical SynthesisBiosynthesisBioorganic ChemistryEngineeringBiochemistryNatural SciencesHigh Overall YieldNatural Product BiosynthesisSynthesis MethodPharmacologyBiomolecular EngineeringNatural Product Synthesis
The efficient and practical synthesis of the biologically important α-galactosylceramides, KRN7000, from phytosphingosine has been achieved in six steps in high overall yield.