Regio- and Chemoselective Ring Opening of Epoxides to Bromohydrins with Dilithium Tetrabromocuprate

Abstract

Dilithium tetrabromocuprate, prepared from lithium bromide and copper(II) bromide, regioselectively converts functionalized epoxides (11 examples) to vicinal bromohydrins resulting from nucleophilic attack by bromide at the less substituted epoxide carbon.