Methanetricarboxylates as key reagents for the simple preparation of heteroarylcarboxamides with potential biological activity. Part 2. Reaction of methanetricarboxylates with 2‐aminopyridine, 2‐aminopyrimidine, 2‐aminothiazole and 2‐aminobenzothiazole

Abstract

Abstract The reaction of methanetricarboxylates 1a,b with 2‐aminopyridine, 2‐aminopyrimidine, 2‐aminothiazole as well as 2‐aminobenzothiazole yields corresponding heteroarylcarboxylic acid esters 2a,b , 5 , 8 , 11a,b . These heterocyclic esters were used as a starting material by the reaction with primary amines to obtaining a number of heteroarylcarboxylic amides 4a‐j , 6 , 10a,b , 13a‐g bearing various substituents on the carboxamide group.