An aminoimidazole and its utility in heterocyclic synthesis

Abstract

Abstract Aminoacetonitrile ( 1 ) reacted with acetamidinium chloride to give 4‐aminoimidazole ( 4 ), which reacted with DMFDMA to yield imidazole derivative 7 and with benzylidinemalononitrile and ethoxymethylene malononitrile to give imidazo[1,5‐ a ]pyrimidine derivatives 12 and 15 . Compound 1 reacted with β‐crotononitrile to yield pyridine derivative 20 . Imidazo[1,2‐ a ]pyridine derivative 23 could be obtained via the reaction of 20 with DMFDMA. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:503–508, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10178