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A Highly Stereoselective Synthesis of the<i>N</i>-Terminal Amino Acid Analogue of Nikkomycin B and Bx
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1994
Year
Highly Stereoselective SynthesisBioorganic ChemistryBiochemistryChiral ChromiumNatural SciencesNikkomycin BMedicineNovel ProcedurePeptide SynthesisOrganic ChemistryStereoselective SynthesisChemical BiologyPharmacologyAsymmetric CatalysisSynthetic ChemistryEnantioselective SynthesisDrug Discovery
A novel procedure for a highly stereoselective preparation of an analogue of the N-terminal amino acid moiety of nikkomycin B and Bx was developed on the basis of a highly diastereoselective aldol reaction of chiral chromium(0)-complexed benzaldehyde derivative.