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A Facile Access to Imidazo[2,1-b]thiazole and Thiazolo[3,2-a]pyrimidine Derivatives
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2001
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Title ProductsDiversity Oriented SynthesisBioorganic ChemistryFacile AccessEfficient MethodNatural SciencesDiversity-oriented SynthesisOrganic ChemistryHeterocycle ChemistryN-dimethylamidines 1PharmacologyDerivative (Chemistry)Synthetic Chemistry
A new and efficient method for the synthesis of 2,3-dihydroimidazo[2,1-b]thiazoles 3, 2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-5-ones 4 and 2,3-dihydro-5H-thiazolo[3,2-a]pyrimidines 5 has been developed. The reactions of N′-(4,5-dihydrothiazol-2-yl)-N,N-dimethylamidines 1 with α-halogenoketones, acid chlorides or acrylic dienophiles were performed, leading to the title products.