Composition of a new chemotype of Tanacetum nubigenum

Abstract

(3R,6R)-Tctrahydro-6-ethenyl-2,2,6-trimethyl-4H-pyran-3-acetate [3R,6R)-linalool oxide acetate] 1 (69.37%) along with 2-hydroxy-4,6-dimethoxyacetophenone 2, (E)- and (Z)-2-(2,4-hexadiynylidene)-l,6-dioxaspiro[4,4]non-3-ene 3 and 4, β-eudesmol 5 and selin-11-en-4α-ol 6 have been isolated from Tanacetum nubigenum Wall of Kumaon region of North Western Himalaya at an altitude of 3600-4300 m. (3R,6R)-linalool oxide acetate 1 has not been reported in Tanacetum species or from any other natural source. Presence of compounds 1-6 and absence of previously reported chrysanthenol and related esters makes it a new chemotype within the genus Tanacetum.