Recent Advances in Metal-Catalyzed Asymmetric Mannich Reactions

Abstract

In this review, recent works on metal-catalyzed asymmetric Mannich, aza-Henry and vinylogous Mannich reactions are described. The asymmetric Mannich reaction is one of the most powerful methodologies among the carbon–carbon bond-forming reactions, and provides direct access to a wide range of optically active natural products with useful biological properties. 1 Introduction 2 Catalytic Asymmetric Mannich Reactions 2.1 BINOL Ligands 2.2 BINAP Ligands 2.3 Bisoxazoline Ligands 2.4 Pyridine Bisoxazoline Ligands 2.5 Diamine Ligands 2.6 <i>P</i>,<i>N</i>-Ligands 2.7<i> P</i>,<i>S</i>-Ligands 2.8<i> P</i>,<i>P</i>-Ligands 2.9<i> N</i>,<i>N</i>-Ligands 2.10 Miscellaneous 3 Asymmetric Aza-Henry Reactions 3.1 BINOL Ligands 3.2 Bisoxazoline Ligands 3.3 <i>N</i>,<i>N</i>-Ligands 3.4 Miscellaneous 4 Asymmetric Vinylogous Mannich Reactions 5 Conclusion