Diastereoselective Synthesis of Substituted Tetrahydroisoquinolines and Isoindolines <i>via</i> a Silver(I) Triflate‐Promoted Tandem Reaction

Abstract

Abstract A new silver(I) triflate‐promoted tandem reaction comprising the ring opening of aziridines and a Michael reaction has been developed. Using secondary amines or primary amines as nucleophiles, this methodology allows for the synthesis of cis ‐1‐alkyl‐4‐aminotetrahydroisoquinolines or cis ‐1,3‐disubstituted isoindolines in good yields with excellent diastereoselectivities, respectively. Besides, easy operation and mild reaction conditions are also notable features of this tandem reaction. magnified image