In Search of an Atom-EconomicalSynthesis of Chiral Ynamides

Abstract

Failed attempts and successes in searching for an atom-economical and efficient synthesis of chiral ynamides are described in this account. These events are illustrated in chronological order, and comparisons are made along the way to reflect other elegant methods known for preparations of ynamides and other electron deficient ynamines. The purpose of this account is to facilitate and revitalize interest in the chemistry of ynamines within the synthetic community.