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Buchwald-Hartwig Amination of β-Chloroacroleins by Lactams and Heteroarylamines

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2007

Year

Abstract

β-Chloroacroleins reacted readily with lactams and several heteroarylamines (aminopyridines, aminoquinoline and azoles) under standard Buchwald-Hartwig amination conditions. Both Pd(OAc)2/Binap or Pd(OAc)2/Xantphos were efficient catalytic systems in the presence of Cs2CO3 as base.