Synthesis and Cytostatic Properties of Some 6<i>H</i>‐Indolo[2, 3‐<i>b</i>][1, 8]naphthyridine Derivatives

Abstract

The new and efficient synthesis of the title heterocyclic ring system is described starting from suitable 2-chloro-1, 8-naphthyridines. The synthesized 6H-indolo[2, 3-b][1, 8]naphthyridine derivatives were tested in vitro on 55 tumor cell lines for their anticancer properties. The presence of the acetylamino moiety at position 3 in the main ring system proved to be crucial for the cytostatic activity of this class of compounds.