Convenient Access to Primary Amines by Employing the Barbier-Type Reaction of <i>N</i>-(Trimethylsilyl)imines Derived from Aromatic and Aliphatic Aldehydes

Abstract

A new versatile preparation of primary amines via benzylation of aromatic and aliphatic aldimines is described. Sonochemical and traditional methods for generation of the reactive intermediates are compared and contrasted. Competitive reactions were analyzed via free energy relationships to support the proposed alkylative mechanism.