A Novel Ring Closure Reaction for the Preparation of 6-Aminouracils with an a-Branched 1-Substituent

Abstract

The preparation of 6-aminouracil derivatives is described involving a novel, silicon-promoted ring closure reaction.Condensation of N-substituted urea with cyanoacetic acid yields cyanoacetylureas, which are heated in hexamethyldisilazane/trimethylchlorosilane to afford N-substituted 6-amino-