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A Convenient Route to Aryl Trifluoromethyl Sulfones by Fluoride-Catalyzed Cross-Coupling of Arenesulfonyl Fluorides with (Trifluoromethyl)trimethylsilane and (Trifluoromethyl)trimethylstannane
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1990
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High YieldsChemical EngineeringCross-coupling ReactionDerivativesEngineeringDerivative (Chemistry)Aromatic CompoundsFluorous SynthesisArenesulfonyl FluoridesOrganic ChemistryAryl Trifluoromethyl SulfonesCatalysisChemistryHalogenationChemical DerivativeCorresponding Sulfonyl FluoridesFluoride-catalyzed Cross-coupling
Trifluoromethylsulfonyl substituted aromatic compounds 3a-d are prepared from the corresponding sulfonyl fluorides 1a-d by reacting with (trifluoromethyl)trimethylsilane (or-stannane) in the presence of a base under mild conditions in high yields.