Enantioselective <i>N</i>-Acetylation of Racemic Secondary Alkyl Amines with Chiral 2-Acetylamino-2′-diacetylamino-1,1′-binaphthyl

Abstract

The enantioselective N-acetylation of racemic secondary alkyl amines with chiral 2-acetylamino-2′-diacetylamino-1,1′-binaphthyl (2) is described. This N-acetylation with 2 was effective for 1-arylethylamine and phenylalanine benzyl ester to give the corresponding N-acetylamines with up to 48% ee.