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Efficient One-Pot Synthesis of Unsymmetrical Cysteine Disulfides
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2008
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Larger PeptidesCombinatorial ChemistryMedicinal ChemistryHeterocyclicBiochemistryUnsymmetrical Cysteine DisulfidesNatural SciencesPeptide SynthesisOrganic ChemistryOne-pot ReactionChemistrySynthesis MethodChemical BiologyPharmacologySynthetic Chemistry
A series of unsymmetrical cysteine disulfides have been prepared in a one-pot reaction using 1-chlorobenzotriazole as the oxidant. The methodology appears to be applicable to larger peptides.