Amberlyst-15-Catalyzed Novel Synthesis of Tetrahydropyranols

Abstract

The cross-coupling reaction of homoallyl alcohols with aldehydes in the presence of Amberlyst-15 resulted in the formation of 4-hydroxy-2,6-disubstituted tetrahydropyrans in high yields with high diastereoselectivity. The stereochemistry of these products was assigned with the assistance of coupling constants and nOe studies.