Synlett · 1992 · 20 citations · 0 references
Combinatorial ChemistryEngineeringPhosphoryl ChlorideOrganic ChemistryChemistryHeterocycle ChemistryNovel OrganocatalystsBiosynthesisConvenient PreparationVilsmeier Formylation ReactionsMethyl PhosphorodichloridateBiochemistryMethyl DichlorophosphatePyrophosphoryl ChlorideSynthesis MethodProtein PhosphorylationBiomolecular EngineeringNatural SciencesPeptide SynthesisSynthetic Chemistry
Methyl phosphorodichloridate (methyl dichlorophosphate) is slowly converted into pyrophosphoryl chloride in good yield in the presence of an excess of phosphoryl chloride: the anhydride forms excellent formylating reagents in combination with N,N-disubstituted formamides.