Publication | Closed Access
Ru-Catalyzed Asymmetric Hydrogenation of γ-Heteroatom Substituted β-Keto Esters
39
Citations
52
References
2011
Year
Key Building BlocksEngineeringNatural SciencesRu-catalyzed Asymmetric HydrogenationDiversity-oriented SynthesisCatalytic SynthesisOrganic ChemistryHigh EnantioselectivitiesCatalysisStereoselective SynthesisChemistryβ-Hydroxy EstersNatural Product SynthesisAsymmetric CatalysisSynthetic ChemistryEnantioselective SynthesisBiomolecular Engineering
A series of enantiomerically pure γ-heteroatom substituted β-hydroxy esters were synthesized with high enantioselectivities (up to 99.1% ee) by hydrogenation of γ-heteroatom substituted β-keto esters in the presence of Ru-(S)-SunPhos catalyst. These asymmetric hydrogenations provide key building blocks for a variety of naturally occurring and biologically active compounds.
| Year | Citations | |
|---|---|---|
Page 1
Page 1