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Synthesis of Morphine-3,6-di-β-D-glucuronide
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1997
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Morphine-6-β-d-glucuronide 12Medicinal ChemistryBioorganic ChemistryNatural SciencesOrganic ChemistryMonolithium SaltPharmacologyLithium HydroxideSynthetic ChemistryNatural Product Synthesis
The synthesis of morphine-3,6-di-β-D-glucuronide as the monolithium salt from a fully protected morphine-6-β-D-glucuronide 12 via selective 3-deacetylation followed by Lewis acid-catalyzed 3-glucuronidation, and stepwise deprotection with lithium hydroxide is described.